b-Barrel Mobility Underlies Closure of the Voltage-Dependent Anion Channel

Ulrich Zachariae,1,3,7 Robert Schneider,2,4,7 Rodolfo Briones,1 Zrinka Gattin,2 Jean-Philippe Demers,2 Karin Giller,2 Elke Maier,5 Markus Zweckstetter,2 Christian Griesinger,2 Stefan Becker,2 Roland Benz,5,6 Bert L. de Groot,1,* and Adam Lange2,* 1Computational Biomolecular Dynamics Group 2Department of NMR-based Structural Biology Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany 3SUPA, School of Physics and Astronomy, The University of Edinburgh, King’s Buildings, Edinburgh EH9 3JZ, UK 4Protein Dynamics and Flexibility by NMR, Institut de Biologie Structurale, 41 rue Jules Horowitz, 38027 Grenoble, France 5Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Würzburg, Versbacher Str. 9, 97078 Würzburg, Germany 6School of Engineering and Science, Jacobs University Bremen, Campusring 1, 28759 Bremen, Germany 7These authors contributed equally to this work *Correspondence: [email protected] (B.L.d.G.), [email protected] (A.L.) http://dx.doi.org/10.1016/j.str.2012.06.015